Lichenoid vulvar dermatoses, which include lichen sclerosus (LS), lichen planus (LP) and lichen simplex chronicus (LSC), are chronic, progressive, inflammatory conditions that are characterized by epithelial thinning and can manifest with a variety of symptoms, most commonly pruritus or pain.11
StrataMGT has been developed for use on all types of mucosal conditions and post-procedures care where the epidermis of the vaginal mucosa is damaged or wounded including:
- Lichen sclerosus (LS)
- Lichen Planus (LP)
- Lichen Simpex Chronicus (LSC)
Lichen Sclerosus (LS):
Lichen Sclerosus (LS):
Lichen sclerosus is a chronic inflammatory autoimmune skin disease that predominantly affects the anogenital region.
- LS and PS are most prevalent in females during the prepubertal and post-menaupose periods.1,12
- While it has been reported in patients of all age groups and in both sexes, lichen sclerosus is most common among postmenopausal women, although it may also appear in childhood (15%). In girls, it typically improves with age but can persist into adulthood.18
- The exact prevalence of vulvar LS (VLS) is unknown but is estimated to range between 0.1% and 3% in the pre-pubertal and postmenopausal periods.12,20
Lichen planus is an inflammatory skin disease that can affect any area of the skin or mucous membranes. The presentation varies depending on severity, the stage of development of the lesions, and the site affected. LP may be localized to the vulvovaginal area, or it may affect this area in the context of more extensive disease.
- It is estimated that the vulva is affected in approximately 50% of women with oral lichen planus.
Lichen simplex chronicus is one of the most common causes of primary vulvar itching, although other pruritic skin diseases also cause this symptom. Primary LSC is a localized chronic type of atopic dermatitis.
- Constant itching and scratching result in thickening of the skin and damage to the protective barrier layer, leading to irritation, increased sensitivity to exogenous substances, superinfection, and perpetuation of the itch-scratch cycle.
- Clinical manifestations include thickened and lichenified plaques and a unilateral or bilateral increase in skin folds.
- Patients with Vulvar LSC report intense pruritus that may disturb sleep. Heat, sweat, and friction may worsen the pruritus and symptoms can remain despite the removal of triggers.